Germ cell transplantation—a fertile field

Abstract

Spermatogonial cell transplantation from a mouse with a defective soma to a mouse with a compromised germ line re-establishes spermatogenesis. The ability of both of these cell types to resume normal function has implications for fertility treatment (29–34).

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: A single Sertoli cell and its associated germ cells, based on those seen within a cross-section through the seminiferous epithelium in the mouse.

References

  1. 1

    Ogawa, T., Dobrinski, I., Avarbock, M.R. & Brinster, R.L. Transplantation of male germ line stem cells restores fertility in infertile mice. Nature Med. 5, 29– 34 (1999).

  2. 2

    Dym, M. Spermatogonial stem cells of the testis. Proc. Natl. Acad. Sci. USA 91, 11287–11289 (1994).

  3. 3

    Brinster, R.L. et al. Spermatogenesis following male germ-cell transplantation. Proc. Natl. Acad. Sci. USA 91, 11298– 11302 (1994).

  4. 4

    Clouthier, D.E. et al. Rat spermatogenesis in mouse testis. Nature 381, 418–421 (1996).

  5. 5

    Blatt, J. Pregnancy outcome in long-term survivors of childhood cancer. Med. Pediatr. Oncol. 33, 29–33 (1999).

  6. 6

    Radford, J.A., Shalet, S.M. & Laberman, B.A. Fertility after treatment for cancer. Br. Med. J. 319, 935–936 (1999).

  7. 7

    Nagano, M. et al. Culture of mouse spermatogonial stem cells. Tissue Cell 30, 389–397 ( 1998).

  8. 8

    Fleischman, R.A. et al. Deletion of the c-kit proto-oncogene in the human developmental defect piebald. Proc. Nat. Acad. Sci. USA 88, 10885–10889 (1991).

  9. 9

    Mcelreavey, K. et al. Male Infertility and the Y Chromosome. Am. J. Hum. Genet. 64, 928–933 ( 1999).

  10. 10

    Page, D.C. et al. Men with infertility caused by AZFc deletion can produce sons by intracytoplasmic sperm injection, but are likely to transmit the deletion and infertility. Hum. Reprod. 14, 1722– 1726 (1999).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Cooke, H., Saunders, P. Germ cell transplantation—a fertile field. Nat Med 6, 16–17 (2000). https://doi.org/10.1038/71469

Download citation

Further reading