Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A human cellular model of amyotrophic lateral sclerosis

Stem cell–derived human motor neurons were used to investigate the cellular mechanisms underlying C9ORF72-related amyotrophic lateral sclerosis.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Intronic repeats in C9ORF72 cause loss of human motor neurons.

Marina Corral Spence/Springer Nature

References

  1. Chan, S., Kaufmann, P., Shungu, D.C. & Mitsumoto, H. Neuroimaging Clin. N. Am. 13, 307–326 (2003).

    Article  Google Scholar 

  2. Leblond, C. S. et al. Exp. Neurol. 262 Pt B, 91–101 (2014).

    Article  Google Scholar 

  3. Renton, A.E., Chiò, A. & Traynor, B.J. Nat. Neurosci. 17, 17–23 (2014).

    Article  CAS  Google Scholar 

  4. Gitler, A.D. & Tsuiji, H. Brain Res. 1647, 19–29 (2016).

    Article  CAS  Google Scholar 

  5. Shi, Y. et al. Nat. Med. 24, 313–325 (2018).

    Article  CAS  Google Scholar 

  6. DeJesus-Hernandez, M. et al. Neuron 72, 245–256 (2011).

    Article  CAS  Google Scholar 

  7. Lagier-Tourenne, C. et al. Proc. Natl. Acad. Sci. USA 110, E4530–E4539 (2013).

    Article  CAS  Google Scholar 

  8. Mizielinska, S. et al. Science 345, 1192–1194 (2014).

    Article  CAS  Google Scholar 

  9. Tran, H. et al. Neuron 87, 1207–1214 (2015).

    Article  CAS  Google Scholar 

  10. Davidson, Y.S. et al. Acta Neuropathol. Commun. 2, 70 (2014).

    Article  Google Scholar 

  11. Lin, C.L. et al. Neuron 20, 589–602 (1998).

    Article  CAS  Google Scholar 

  12. Chow, C.Y. et al. Am. J. Hum. Genet. 84, 85–88 (2009).

    Article  CAS  Google Scholar 

  13. Paşca, S.P. Nature 553, 437–455 (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sergiu P Paşca.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Marton, R., Paşca, S. A human cellular model of amyotrophic lateral sclerosis. Nat Med 24, 256–257 (2018). https://doi.org/10.1038/nm.4509

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.4509

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing