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A human cellular model of amyotrophic lateral sclerosis

Stem cell–derived human motor neurons were used to investigate the cellular mechanisms underlying C9ORF72-related amyotrophic lateral sclerosis.

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Figure 1: Intronic repeats in C9ORF72 cause loss of human motor neurons.

Marina Corral Spence/Springer Nature


  1. Chan, S., Kaufmann, P., Shungu, D.C. & Mitsumoto, H. Neuroimaging Clin. N. Am. 13, 307–326 (2003).

    Article  Google Scholar 

  2. Leblond, C. S. et al. Exp. Neurol. 262 Pt B, 91–101 (2014).

    Article  Google Scholar 

  3. Renton, A.E., Chiò, A. & Traynor, B.J. Nat. Neurosci. 17, 17–23 (2014).

    Article  CAS  Google Scholar 

  4. Gitler, A.D. & Tsuiji, H. Brain Res. 1647, 19–29 (2016).

    Article  CAS  Google Scholar 

  5. Shi, Y. et al. Nat. Med. 24, 313–325 (2018).

    Article  CAS  Google Scholar 

  6. DeJesus-Hernandez, M. et al. Neuron 72, 245–256 (2011).

    Article  CAS  Google Scholar 

  7. Lagier-Tourenne, C. et al. Proc. Natl. Acad. Sci. USA 110, E4530–E4539 (2013).

    Article  CAS  Google Scholar 

  8. Mizielinska, S. et al. Science 345, 1192–1194 (2014).

    Article  CAS  Google Scholar 

  9. Tran, H. et al. Neuron 87, 1207–1214 (2015).

    Article  CAS  Google Scholar 

  10. Davidson, Y.S. et al. Acta Neuropathol. Commun. 2, 70 (2014).

    Article  Google Scholar 

  11. Lin, C.L. et al. Neuron 20, 589–602 (1998).

    Article  CAS  Google Scholar 

  12. Chow, C.Y. et al. Am. J. Hum. Genet. 84, 85–88 (2009).

    Article  CAS  Google Scholar 

  13. Paşca, S.P. Nature 553, 437–455 (2018).

    Article  Google Scholar 

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Correspondence to Sergiu P Paşca.

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Marton, R., Paşca, S. A human cellular model of amyotrophic lateral sclerosis. Nat Med 24, 256–257 (2018).

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