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Selective enhancer changes in osteosarcoma lung metastasis

A recent study investigates the contribution of epigenomic plasticity to lung metastasis in osteosarcoma. Changes in the enhancer landscape were found to be nonrandom and driven by selective forces in the microenvironment.

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Figure 1: Environmentally induced alterations in enhancers drive metastasis in osteosarcoma.

Marina Corral Spence/Springer Nature


  1. Wan, L., Pantel, K. & Kang, Y. Nat. Med. 19, 1450–1464 (2013).

    Article  CAS  Google Scholar 

  2. Lamouille, S., Xu, J. & Derynck, R. Nat. Rev. Mol. Cell Biol. 15, 178–196 (2014).

    Article  CAS  Google Scholar 

  3. Zhu, J. et al. Cell 152, 642–654 (2013).

    Article  CAS  Google Scholar 

  4. McDonald, O.G. et al. Nat. Genet. 49, 367–376 (2017).

    Article  CAS  Google Scholar 

  5. Makohon-Moore, A.P. et al. Nat. Genet. 49, 358–366 (2017).

    Article  CAS  Google Scholar 

  6. Roe, J.S. et al. Cell 170, 875–888 (2017).

    Article  CAS  Google Scholar 

  7. Sheffield, N.C. et al. Nat. Med. 23, 386–395 (2017).

    Article  CAS  Google Scholar 

  8. Morrow, J.J. et al. Nat. Med. 24, 176–185 (2018).

    Article  CAS  Google Scholar 

  9. Mendoza, A. et al. J. Clin. Invest. 120, 2979–2988 (2010).

    Article  CAS  Google Scholar 

  10. Wagner, E.F. Ann. Rheum. Dis. 61 (Suppl. 2), :ii40–ii42 (2002).

    Article  CAS  Google Scholar 

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Correspondence to Heinrich Kovar.

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Kovar, H. Selective enhancer changes in osteosarcoma lung metastasis. Nat Med 24, 126–127 (2018).

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