A recent study investigates the contribution of epigenomic plasticity to lung metastasis in osteosarcoma. Changes in the enhancer landscape were found to be nonrandom and driven by selective forces in the microenvironment.
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References
Wan, L., Pantel, K. & Kang, Y. Nat. Med. 19, 1450–1464 (2013).
Lamouille, S., Xu, J. & Derynck, R. Nat. Rev. Mol. Cell Biol. 15, 178–196 (2014).
Zhu, J. et al. Cell 152, 642–654 (2013).
McDonald, O.G. et al. Nat. Genet. 49, 367–376 (2017).
Makohon-Moore, A.P. et al. Nat. Genet. 49, 358–366 (2017).
Roe, J.S. et al. Cell 170, 875–888 (2017).
Sheffield, N.C. et al. Nat. Med. 23, 386–395 (2017).
Morrow, J.J. et al. Nat. Med. 24, 176–185 (2018).
Mendoza, A. et al. J. Clin. Invest. 120, 2979–2988 (2010).
Wagner, E.F. Ann. Rheum. Dis. 61 (Suppl. 2), :ii40–ii42 (2002).
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Kovar, H. Selective enhancer changes in osteosarcoma lung metastasis. Nat Med 24, 126–127 (2018). https://doi.org/10.1038/nm.4487
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DOI: https://doi.org/10.1038/nm.4487
This article is cited by
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Aberrant activation of CYR61 enhancers in colorectal cancer development
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