Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Lipid metabolic reprogramming in hepatic ischemia–reperfusion injury

Nature Medicine volume 24, pages 6–7 (2018)Cite this article

Subjects

In a recent study of hepatic ischemia–reperfusion injury (IRI), Zhang et al. use tandem 'omics' approaches in mice, pigs, and nonhuman primates to identify lipid metabolic reprogramming as a key determinant of IRI, thus providing novel mechanistic and therapeutic insights.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Identification of a novel therapeutic target, ALOX12, in hepatic IRI.

Marina Corral Spence/Springer Nature

References

  1. Eltzschig, H.K. & Eckle, T. Nat. Med. 17, 1391–1401 (2011).

    Article  CAS  Google Scholar 

  2. Zhai, Y., Petrowsky, H., Hong, J.C., Busuttil, R.W. & Kupiec-Weglinski, J.W. Nat. Rev. Gastroenterol. Hepatol. 10, 79–89 (2013).

    Article  CAS  Google Scholar 

  3. Jennings, R.B., Sommers, H.M., Smyth, G.A., Flack, H.A. & Linn, H. Arch. Pathol. 70, 68–78 (1960).

    CAS  PubMed  Google Scholar 

  4. Konishi, T. & Lentsch, A.B. Gene Expr. 17, 277–287 (2017).

    Article  CAS  Google Scholar 

  5. van Golen, R.F., van Gulik, T.M. & Heger, M. Cytokine Growth Factor Rev. 23, 69–84 (2012).

    Article  CAS  Google Scholar 

  6. Chouchani, E.T. et al. Nature 515, 431–435 (2014).

    Article  CAS  Google Scholar 

  7. Zhang, P. et al. Nat. Med. 24, 84–94 (2018).

    Article  CAS  Google Scholar 

  8. Husted, A.S., Trauelsen, M., Rudenko, O., Hjorth, S.A. & Schwartz, T.W. Cell Metab. 25, 777–796 (2017).

    Article  CAS  Google Scholar 

  9. Ackermann, J.A., Hofheinz, K., Zaiss, M.M. & Krönke, G. Biochim. Biophys. Acta 1862, 371–381 (2017).

    Article  CAS  Google Scholar 

  10. Luci, D.K. et al. J. Med. Chem. 57, 495–506 (2014).

    Article  CAS  Google Scholar 

  11. McGonigle, P. & Ruggeri, B. Biochem. Pharmacol. 87, 162–171 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Experimental Pathology, Department of Pathology,

    Satdarshan P Monga

  2. the Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA

    Satdarshan P Monga

  3. the Pittsburgh Liver Research Center, University of Pittsburgh Medical Center and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Satdarshan P Monga

Authors
  1. Satdarshan P Monga
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Satdarshan P Monga.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Monga, S. Lipid metabolic reprogramming in hepatic ischemia–reperfusion injury. Nat Med 24, 6–7 (2018). https://doi.org/10.1038/nm.4468

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.4468

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing