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Targeted cellular immunotherapy for T cell malignancies

In a recent study, Maciocia et al. develop a novel T cell receptor beta (TCRB) constant C1-chain-directed cellular immunotherapy for the treatment of T cell malignancies.

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Figure 1: Principles of anti-TCRB-C1 CAR T cell therapy.


  1. Pishko, A. & Nasta, S.D. Transl. Cancer Res. 6, 93–103 (2017).

    Article  CAS  Google Scholar 

  2. Ramos, C.A. et al. J. Clin. Invest. 126, 2588–2596 (2016).

    Article  Google Scholar 

  3. Toyonaga, B., Yoshikai, Y., Vadasz, V., Chin, B. & Mak, T.W. Proc. Natl. Acad. Sci. USA 82, 8624–8628 (1985).

    Article  CAS  Google Scholar 

  4. Schwartz, R.H. Annu. Rev. Immunol. 3, 237–261 (1985).

    Article  CAS  Google Scholar 

  5. Warner, K. et al. Curr. Hematol. Malig. Rep. 8, 163–172 (2013).

    Article  Google Scholar 

  6. Nikolich-Zugich, J., Slifka, M.K. & Messaoudi, I. Nat. Rev. Immunol. 4, 123–132 (2004).

    Article  CAS  Google Scholar 

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Correspondence to Adolfo Ferrando.

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The authors declare no competing financial interests.

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Palomero, T., Ferrando, A. Targeted cellular immunotherapy for T cell malignancies. Nat Med 23, 1402–1403 (2017).

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