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Recognition of self-DNA drives cardiac inflammation: why broken hearts fail

Signals that govern immune cells in the heart remain poorly defined. A new report in mice shows that pathways involved in sensing viruses orchestrate monocyte and macrophage activation through recognition of DNA derived from dying cardiomyocytes following myocardial infarction.

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Figure 1: The role of cGAS–STING signaling in cardiac inflammation following myocardial infarction.


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Correspondence to Kory J Lavine.

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Lavine, K., Mann, D. Recognition of self-DNA drives cardiac inflammation: why broken hearts fail. Nat Med 23, 1400–1401 (2017).

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