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Acknowledgements

We would like to thank S. Geschwindner for critical comments and discussion on the manuscript. We would like to thank G.J. Augustine (Korea Institute of Science and Technology) for generously providing the SuperClomeleon construct. This work was supported by funding from AstraZeneca, a grant from the Simons Foundation (206026 to S.J.M.), NIH–NINDS grants NS051195, NS056359, NS081735, and NS087662 (S.J.M.), and NIH–NIMH MH097446 (P.A.D.).

Author information

Author notes

    • Ross A Cardarelli
    • , Karen Jones
    •  & Lucie I Pisella

    These authors contributed equally to this work.

Affiliations

  1. AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.

    • Ross A Cardarelli
    • , Heike J Wobst
    • , Liliya Silayeva
    • , Qi Wang
    • , Nicholas J Brandon
    • , Tarek Z Deeb
    •  & Stephen J Moss
  2. Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK.

    • Karen Jones
    • , Paul M Sharpe
    •  & Matthew P Burnham
  3. INMED, INSERM, Unité 901, Marseille, France.

    • Lucie I Pisella
    • , Ilona Chudotvorova
    • , Justine Guyot
    •  & Igor Medina
  4. Aix–Marseille Université, UMR 901, Marseille, France.

    • Lucie I Pisella
    • , Ilona Chudotvorova
    • , Justine Guyot
    •  & Igor Medina
  5. Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA.

    • Heike J Wobst
    • , Stephen Zicha
    • , Jörg Holenz
    • , Mark E Duggan
    • , John Dunlop
    • , Robert J Mather
    • , Qi Wang
    •  & Nicholas J Brandon
  6. Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.

    • Lisa J McWilliams
    •  & David J Baker
  7. Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.

    • Danielle H Morrow
    • , Paul A Davies
    •  & Stephen J Moss
  8. Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

    • Niek Dekker
  9. Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.

    • Stephen J Moss

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Contributions

R.A.C., T.Z.D., I.M., P.A.D., S.Z., J.D., R.J.M., N.J.B., and S.J.M. designed experiments. R.A.C., K.J., L.I.P., H.J.W., L.J.M., D.J.B., I.C., J.G., L.S., and T.Z.D. performed all the experiments and subsequent analysis. P.M.S., M.P.B., D.H.M., N.D., J.H., M.E.D., R.J.M., and Q.W. produced all reagents or oversaw production of reagents. R.A.C., T.Z.D., I.M., N.J.B., and S.J.M. wrote the manuscript.

Competing interests

K.J., L.J.M., P.M.S., M.P.B., D.J.B., N.D., R.J.M., S.Z., Q.W., J.H., M.E.D., J.D., and N.J.B. are or were full-time employees and shareholders of AstraZeneca. S.J.M. serves as a consultant for SAGE therapeutics and AstraZeneca; these relationships are regulated by Tufts University.

Corresponding authors

Correspondence to Nicholas J Brandon or Tarek Z Deeb or Stephen J Moss.

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DOI

https://doi.org/10.1038/nm.4442

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