News & Views | Published:

Long-range hypoxia signaling in NAFLD

Nature Medicine volume 23, pages 12511252 (2017) | Download Citation

A recent study describes a role for hypoxic signaling in the small intestine in the etiology of nonalcoholic fatty liver disease (NAFLD) and suggests that HIF-2α inhibitors may be an effective option for the treatment of this disease.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , , & J. Am. Med. Assoc. 315, 2284–2291 (2016).

  2. 2.

    et al. Nat. Rev. Gasroenterol. Hepatol. (2017).

  3. 3.

    et al. Nat. Med. 23, 1298–1308 (2017).

  4. 4.

    , , , & Trends Endocrinol. Metab. 23, 365–371 (2012).

  5. 5.

    et al. Mol. Cell. Biol. 29, 4527–4538 (2009).

  6. 6.

    et al. Nat. Med. 19, 1325–1330 (2013).

  7. 7.

    et al. Nat. Med. 19, 1331–1337 (2013).

  8. 8.

    et al. Cell Metab. 23, 505–516 (2016).

  9. 9.

    et al. Diabetes 56, 901–911 (2007).

  10. 10.

    , , , & Cell Metab. 14, 491–503 (2011).

  11. 11.

    , , , & Crit. Rev. Oncol. Hematol. 111, 117–123 (2017).

Download references

Author information

Affiliations

  1. Edward L. LaGory and Amato J. Giaccia are in the Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University, Stanford, California, USA.

    • Edward L LaGory
    •  & Amato J Giaccia

Authors

  1. Search for Edward L LaGory in:

  2. Search for Amato J Giaccia in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Amato J Giaccia.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nm.4436

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing