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Long-range hypoxia signaling in NAFLD

A recent study describes a role for hypoxic signaling in the small intestine in the etiology of nonalcoholic fatty liver disease (NAFLD) and suggests that HIF-2α inhibitors may be an effective option for the treatment of this disease.

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Figure 1: Intestinal HIF-2α promotes NAFLD.

Katie Vicari/Springer Nature

References

  1. Flegal, K.M., Kruszon-Moran, D., Carroll, M.D., Fryar, C.D. & Ogden, C.L. J. Am. Med. Assoc. 315, 2284–2291 (2016).

    Article  CAS  Google Scholar 

  2. Younossi, Z. et al. Nat. Rev. Gasroenterol. Hepatol. http://dx.doi.org/10.1038/nrgastro.2017.109 (2017).

  3. Xie, C. et al. Nat. Med. 23, 1298–1308 (2017).

    Article  CAS  Google Scholar 

  4. Pagadala, M., Kasumov, T., McCullough, A.J., Zein, N.N. & Kirwan, J.P. Trends Endocrinol. Metab. 23, 365–371 (2012).

    Article  CAS  Google Scholar 

  5. Rankin, E.B. et al. Mol. Cell. Biol. 29, 4527–4538 (2009).

    Article  CAS  Google Scholar 

  6. Taniguchi, C.M. et al. Nat. Med. 19, 1325–1330 (2013).

    Article  CAS  Google Scholar 

  7. Wei, K. et al. Nat. Med. 19, 1331–1337 (2013).

    Article  CAS  Google Scholar 

  8. Ramakrishnan, S.K. et al. Cell Metab. 23, 505–516 (2016).

    Article  CAS  Google Scholar 

  9. Hosogai, N. et al. Diabetes 56, 901–911 (2007).

    Article  CAS  Google Scholar 

  10. Lee, K.Y., Gesta, S., Boucher, J., Wang, X.L. & Kahn, C.R. Cell Metab. 14, 491–503 (2011).

    Article  CAS  Google Scholar 

  11. Martínez-Sáez, O., Gajate Borau, P., Alonso-Gordoa, T., Molina-Cerrillo, J. & Grande, E. Crit. Rev. Oncol. Hematol. 111, 117–123 (2017).

    Article  Google Scholar 

Download references

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Correspondence to Amato J Giaccia.

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LaGory, E., Giaccia, A. Long-range hypoxia signaling in NAFLD. Nat Med 23, 1251–1252 (2017). https://doi.org/10.1038/nm.4436

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