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Long-range hypoxia signaling in NAFLD

A recent study describes a role for hypoxic signaling in the small intestine in the etiology of nonalcoholic fatty liver disease (NAFLD) and suggests that HIF-2α inhibitors may be an effective option for the treatment of this disease.

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Figure 1: Intestinal HIF-2α promotes NAFLD.

Katie Vicari/Springer Nature

References

  1. 1

    Flegal, K.M., Kruszon-Moran, D., Carroll, M.D., Fryar, C.D. & Ogden, C.L. J. Am. Med. Assoc. 315, 2284–2291 (2016).

    CAS  Article  Google Scholar 

  2. 2

    Younossi, Z. et al. Nat. Rev. Gasroenterol. Hepatol. http://dx.doi.org/10.1038/nrgastro.2017.109 (2017).

  3. 3

    Xie, C. et al. Nat. Med. 23, 1298–1308 (2017).

    CAS  Article  Google Scholar 

  4. 4

    Pagadala, M., Kasumov, T., McCullough, A.J., Zein, N.N. & Kirwan, J.P. Trends Endocrinol. Metab. 23, 365–371 (2012).

    CAS  Article  Google Scholar 

  5. 5

    Rankin, E.B. et al. Mol. Cell. Biol. 29, 4527–4538 (2009).

    CAS  Article  Google Scholar 

  6. 6

    Taniguchi, C.M. et al. Nat. Med. 19, 1325–1330 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Wei, K. et al. Nat. Med. 19, 1331–1337 (2013).

    CAS  Article  Google Scholar 

  8. 8

    Ramakrishnan, S.K. et al. Cell Metab. 23, 505–516 (2016).

    CAS  Article  Google Scholar 

  9. 9

    Hosogai, N. et al. Diabetes 56, 901–911 (2007).

    CAS  Article  Google Scholar 

  10. 10

    Lee, K.Y., Gesta, S., Boucher, J., Wang, X.L. & Kahn, C.R. Cell Metab. 14, 491–503 (2011).

    CAS  Article  Google Scholar 

  11. 11

    Martínez-Sáez, O., Gajate Borau, P., Alonso-Gordoa, T., Molina-Cerrillo, J. & Grande, E. Crit. Rev. Oncol. Hematol. 111, 117–123 (2017).

    Article  Google Scholar 

Download references

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Correspondence to Amato J Giaccia.

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LaGory, E., Giaccia, A. Long-range hypoxia signaling in NAFLD. Nat Med 23, 1251–1252 (2017). https://doi.org/10.1038/nm.4436

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