News & Views | Published:

An epitranscriptomic vulnerability in myeloid malignancies

Nature Medicine volume 23, pages 12521254 (2017) | Download Citation

A recent study finds that the N6-methyladenosine (m6A) modifier METTL3 regulates proliferation and differentiation in myeloid cells and acute myeloid leukemia (AML).

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nat. Rev. Dis. Primers 2, 16010 (2016).

  2. 2.

    et al. Cell Stem Cell 15, 707–719 (2014).

  3. 3.

    et al. Science 347, 1002–1006 (2015).

  4. 4.

    et al. Nature 548, 338–342 (2017).

  5. 5.

    et al. Nat. Med. 23, 1369–1376 (2017).

  6. 6.

    Genomics Proteomics Bioinformatics 15, 154–163 (2017).

  7. 7.

    Nat. Rev. Genet. 8, 533–543 (2007).

  8. 8.

    et al. Nat. Struct. Mol. Biol. 24, 870–878 (2017).

  9. 9.

    et al. Nature 518, 560–564 (2015).

  10. 10.

    et al. Nature 519, 486–490 (2015).

  11. 11.

    et al. Cell Rep. 18, 2622–2634 (2017).

  12. 12.

    et al. Cancer Cell 31, 591–606 (2017).

Download references

Author information

Affiliations

  1. Alexandra C. Schmiechen and Pedro J. Batista are in the Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.

    • Alexandra C Schmiechen
    •  & Pedro J Batista

Authors

  1. Search for Alexandra C Schmiechen in:

  2. Search for Pedro J Batista in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Pedro J Batista.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nm.4435

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing