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Engineering MeCP2 to spy on its targets

Nature Medicine volume 23, pages 11201122 (2017) | Download Citation

A new mouse model of Rett syndrome, in which MECP2 can be selectively biotinylated, allows for the investigation of cell-specific effects of Rett-causing mutations on gene expression, particularly in female mice.

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Author information

Affiliations

  1. Patricia M. Horvath and Lisa M. Monteggia are in the Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

    • Patricia M Horvath
    •  & Lisa M Monteggia

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  1. Search for Patricia M Horvath in:

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Lisa M Monteggia.

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DOI

https://doi.org/10.1038/nm.4425

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