Devereux, G. The increase in the prevalence of asthma and allergy: food for thought. Nat. Rev. Immunol. 6, 869–874 (2006).
Kalesnikoff, J. & Galli, S.J. New developments in mast cell biology. Nat. Immunol. 9, 1215–1223 (2008).
Serhan, C.N. Pro-resolving lipid mediators are leads for resolution physiology. Nature 510, 92–101 (2014).
Nagakura, T., Matsuda, S., Shichijyo, K., Sugimoto, H. & Hata, K. Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. Eur. Respir. J. 16, 861–865 (2000).
Peat, J.K. et al. Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study. J. Allergy Clin. Immunol. 114, 807–813 (2004).
Murakami, M. et al. Recent progress in phospholipase A2 research: from cells to animals to humans. Prog. Lipid Res. 50, 152–192 (2011).
Sugiyama, H. et al. Peroxisome proliferator–activated receptors are expressed in mouse bone marrow–derived mast cells. FEBS Lett. 467, 259–262 (2000).
Murakami, M., Matsumoto, R., Urade, Y., Austen, K.F. & Arm, J.P. c-Kit ligand mediates increased expression of cytosolic phospholipase A2, prostaglandin endoperoxide synthase-1, and hematopoietic prostaglandin D2 synthase and increased IgE-dependent prostaglandin D2 generation in immature mouse mast cells. J. Biol. Chem. 270, 3239–3246 (1995).
Fujishima, H. et al. Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow–derived mast cells. Proc. Natl. Acad. Sci. USA 96, 4803–4807 (1999).
Uozumi, N. et al. Role of cytosolic phospholipase A2 in allergic response and parturition. Nature 390, 618–622 (1997).
Bae, K. et al. Platelet-activating factor (PAF)-dependent transacetylase and its relationship with PAF acetylhydrolases. J. Biol. Chem. 275, 26704–26709 (2000).
Costello, P.S. et al. Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene 13, 2595–2605 (1996).
Nishida, K. et al. FcɛRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J. Cell Biol. 170, 115–126 (2005).
Lee, J.H. et al. The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice. J. Immunol. 187, 1807–1815 (2011).
Hong, H. et al. The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood 110, 2511–2519 (2007).
Suzuki, R. et al. Molecular editing of cellular responses by the high-affinity receptor for IgE. Science 343, 1021–1025 (2014).
Matsuzawa, A., Hattori, K., Aoki, J., Arai, H. & Inoue, K. Protection against oxidative stress–induced cell death by intracellular platelet-activating factor–acetylhydrolase II. J. Biol. Chem. 272, 32315–32320 (1997).
Morisseau, C. & Hammock, B.D. Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu. Rev. Pharmacol. Toxicol. 53, 37–58 (2013).
Stafforini, D.M. et al. Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J. Biol. Chem. 281, 4616–4623 (2006).
Adibekian, A. et al. Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors. Nat. Chem. Biol. 7, 469–478 (2011).
Di Stefano, P. et al. p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. EMBO J. 26, 2843–2855 (2007).
Latour, S. & Veillette, A. Proximal protein tyrosine kinases in immunoreceptor signaling. Curr. Opin. Immunol. 13, 299–306 (2001).
Li, J.P. et al. The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Nat. Commun. 5, 3618 (2014).
Yoshioka, K. et al. Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat. Med. 18, 1560–1569 (2012).
Taketomi, Y. et al. Mast cell maturation is driven via a group III phospholipase A2–prostaglandin D2–DP1 receptor paracrine axis. Nat. Immunol. 14, 554–563 (2013).
Vadas, P. et al. Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. N. Engl. J. Med. 358, 28–35 (2008).
Hercule, H.C. et al. The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BKα channel subunit in rodents. Exp. Physiol. 92, 1067–1076 (2007).
López-Vicario, C. et al. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides. Proc. Natl. Acad. Sci. USA 112, 536–541 (2015).
Zhang, G. et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc. Natl. Acad. Sci. USA 110, 6530–6535 (2013).
Aldrovandi, M. et al. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. J. Lipid Res. 54, 3085–3097 (2013).
Sugiyama, H. et al. Peroxisome proliferator–activated receptors are expressed in human cultured mast cells: a possible role of these receptors in negative regulation of mast cell activation. Eur. J. Immunol. 30, 3363–3370 (2000).
Torres, R.C. et al. Activation of PPARγ by restores mast cell numbers and reactivity in alloxan-diabetic rats by reducing the systemic glucocorticoid levels. Eur. J. Pharmacol. 691, 261–267 (2012).
Ahmadian, M. et al. PPARγ signaling and metabolism: the good, the bad and the future. Nat. Med. 19, 557–566 (2013).
Wakabayashi, K. et al. The peroxisome proliferator–activated receptor γ/retinoid X receptor α heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol. Cell. Biol. 29, 3544–3555 (2009).
Szatmari, I. et al. PPARγ regulates the function of human dendritic cells primarily by altering lipid metabolism. Blood 110, 3271–3280 (2007).
Step, S.E. et al. Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers. Genes Dev. 28, 1018–1028 (2014).
Ohtake, H., Ichikawa, N., Okada, M. & Yamashita, T. Transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcɛRI. J. Immunol. 168, 2087–2090 (2002).
Broadfield, E.C. et al. A case–control study of dietary and erythrocyte membrane fatty acids in asthma. Clin. Exp. Allergy 34, 1232–1236 (2004).
Woods, R.K., Raven, J.M., Walters, E.H., Abramson, M.J. & Thien, F.C. Fatty acid levels and risk of asthma in young adults. Thorax 59, 105–110 (2004).
Almqvist, C. et al. Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years. J. Allergy Clin. Immunol. 119, 1438–1444 (2007).
Chiurchiù, V. et al. Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses. Sci. Transl. Med. 8, 353ra111 (2016).
Colegio, O.R. et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 513, 559–563 (2014).
Miki, Y. et al. Dual roles of group IID phospholipase A2 in inflammation and cancer. J. Biol. Chem. 291, 15588–15601 (2016).
Rivera, J., Kinet, J.P., Kim, J., Pucillo, C. & Metzger, H. Studies with a monoclonal antibody to the β subunit of the receptor with high affinity for immunoglobulin E. Mol. Immunol. 25, 647–661 (1988).
Kono, N. et al. Protection against oxidative stress–induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo. J. Biol. Chem. 283, 1628–1636 (2008).
Yoda, E. et al. Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of group VIB Ca2+-independent phospholipase A2γ-deficient mice. J. Lipid Res. 51, 3003–3015 (2010).
Bligh, E.G. & Dyer, W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911–917 (1959).
Fujisawa, D. et al. Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria. J. Allergy Clin. Immunol. 134, 622–633 (2014).
Lee, H. et al. Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through Fcγ receptor I and Fcγ receptor II. Arthritis Rheum. 65, 109–119 (2013).