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GDF15 and energy balance: homing in on a mechanism

Nature Medicine volume 23, pages 11191120 (2017) | Download Citation

Three recent studies in mice have identified a specific receptor, GFRAL, for the known anorectic peptide GDF15. The finding increases mechanistic understanding of its effect and paves the way for the development of novel anti-obesity therapeutics.

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Affiliations

  1. Irene Cimino, Anthony P. Coll and Giles S.H. Yeo are at the MRC Metabolic Diseases Unit and Metabolic Research Laboratories, Wellcome Trust–MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital Cambridge, Cambridge, UK.

    • Irene Cimino
    • , Anthony P Coll
    •  & Giles S H Yeo

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Giles S H Yeo.

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DOI

https://doi.org/10.1038/nm.4414

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