Cripps, C., Winquist, E., Devries, M.C., Stys-Norman, D. & Gilbert, R. Epidermal growth factor receptor targeted therapy in stages III and IV head and neck cancer. Curr. Oncol. 17, 37–48 (2010).
Montero, P.H. et al. Changing trends in smoking and alcohol consumption in patients with oral cancer treated at Memorial Sloan-Kettering Cancer Center from 1985 to 2009. Arch. Otolaryngol. Head Neck Surg. 138, 817–822 (2012).
Krishna Rao, S.V., Mejia, G., Roberts-Thomson, K. & Logan, R. Epidemiology of oral cancer in Asia in the past decade—an update (2000–2012). Asian Pac. J. Cancer Prev. 14, 5567–5577 (2013).
Warnakulasuriya, S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 45, 309–316 (2009).
Ng, J.H., Iyer, N.G., Tan, M.H. & Edgren, G. Changing epidemiology of oral squamous cell carcinoma of the tongue: a global study. Head Neck 39, 297–304 (2017).
Ferlay, J. et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer 136, E359–E386 (2015).
Sacco, A.G. & Cohen, E.E. Current treatment options for recurrent or metastatic head and neck squamous cell carcinoma. J. Clin. Oncol. 33, 3305–3313 (2015).
Vermorken, J.B. et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N. Engl. J. Med. 359, 1116–1127 (2008).
Echarri, M.J., Lopez-Martin, A. & Hitt, R. Targeted therapy in locally advanced and recurrent/metastatic head and neck squamous cell carcinoma (LA-R/M HNSCC). Cancers (Basel) 8, E27 (2016).
Licitra, L. et al. Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study. Ann. Oncol. 22, 1078–1087 (2011).
Stewart, J.S. et al. Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck. J. Clin. Oncol. 27, 1864–1871 (2009).
Kirby, A.M. et al. Gefitinib (ZD1839, Iressa) as palliative treatment in recurrent or metastatic head and neck cancer. Br. J. Cancer 94, 631–636 (2006).
Cohen, E.E. et al. Phase II trial of gefitinib 250 mg daily in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. Clin. Cancer Res. 11, 8418–8424 (2005).
Thomas, F. et al. Pilot study of neoadjuvant treatment with erlotinib in nonmetastatic head and neck squamous cell carcinoma. Clin. Cancer Res. 13, 7086–7092 (2007).
Soulieres, D. et al. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J. Clin. Oncol. 22, 77–85 (2004).
Tan, D.S. et al. Biomarker-driven early clinical trials in oncology: a paradigm shift in drug development. Cancer J. 15, 406–420 (2009).
Vettore, A.L. et al. Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance. Genome Med. 7, 98 (2015).
Tan, D.S. et al. Tongue carcinoma infrequently harbor common actionable genetic alterations. BMC Cancer 14, 679 (2014).
Cohen, E.E. et al. Factors associated with clinical benefit from epidermal growth factor receptor inhibitors in recurrent and metastatic squamous cell carcinoma of the head and neck. Oral Oncol. 45, e155–e160 (2009).
Tan, E.H. et al. Gefitinib, cisplatin, and concurrent radiotherapy for locally advanced head and neck cancer: EGFR FISH, protein expression, and mutational status are not predictive biomarkers. Ann. Oncol. 23, 1010–1016 (2012).
Taguchi, T., Tsukuda, M., Imagawa-Ishiguro, Y., Kato, Y. & Sano, D. Involvement of EGFR in the response of squamous cell carcinoma of the head and neck cell lines to gefitinib. Oncol. Rep. 19, 65–71 (2008).
Leong, H.S. et al. Targeting cancer stem cell plasticity through modulation of epidermal growth factor and insulin-like growth factor receptor signaling in head and neck squamous cell cancer. Stem Cells Transl. Med. 3, 1055–1065 (2014).
Guillaudeau, A. et al. Adult diffuse gliomas produce mRNA transcripts encoding EGFR isoforms lacking a tyrosine kinase domain. Int. J. Oncol. 40, 1142–1152 (2012).
Adamczyk, K.A. et al. Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. Life Sci. 89, 304–312 (2011).
Chia, S. et al. Phenotype-driven precision oncology—guiding clinical decisions one patient-at-a-time. Nat. Commun. (in the press).
Iyer, M.K. et al. The landscape of long noncoding RNAs in the human transcriptome. Nat. Genet. 47, 199–208 (2015).
Schmitt, A.M. & Chang, H.Y. Long noncoding RNAs in cancer pathways. Cancer Cell 29, 452–463 (2016).
Brown, J.A. et al. Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix. Nat. Struct. Mol. Biol. 21, 633–640 (2014).
Qi, H.L. et al. The long noncoding RNA, EGFR-AS1, a target of GHR, increases the expression of EGFR in hepatocellular carcinoma. Tumour Biol. 37, 1079–1089 (2016).
Blythe, A.J., Fox, A.H. & Bond, C.S. The ins and outs of lncRNA structure: how, why and what comes next? Biochim. Biophys. Acta 1859, 46–58 (2016).
Ji, Z., Song, R., Regev, A. & Struhl, K. Many lncRNAs, 5′UTRs, and pseudogenes are translated and some are likely to express functional proteins. eLife 4, e08890 (2015).
Munroe, S.H. & Lazar, M.A. Inhibition of c-erbA mRNA splicing by a naturally occurring antisense RNA. J. Biol. Chem. 266, 22083–22086 (1991).
Halle, C. et al. Membranous expression of ectodomain isoforms of the epidermal growth factor receptor predicts outcome after chemoradiotherapy of lymph node–negative cervical cancer. Clin. Cancer Res. 17, 5501–5512 (2011).
Lococo, F. et al. Preliminary evidence on the diagnostic and molecular role of circulating soluble EGFR in non–small cell lung cancer. Int. J. Mol. Sci. 16, 19612–19630 (2015).
Romero-Ventosa, E.Y. et al. Pretreatment levels of the serum biomarkers CEA, CYFRA 21-1, SCC and the soluble EGFR and its ligands EGF, TGF-α, HB-EGF in the prediction of outcome in erlotinib treated non-small-cell lung cancer patients. Springerplus 4, 171 (2015).
Albitar, L. et al. EGFR isoforms and gene regulation in human endometrial cancer cells. Mol. Cancer 9, 166 (2010).
Zhou, T., Kim, Y. & MacLeod, A.R. Targeting long noncoding RNA with antisense oligonucleotide technology as cancer therapeutics. Methods Mol. Biol. 1402, 199–213 (2016).
Golan, T. et al. RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients. Oncotarget 6, 24560–24570 (2015).
Tan, D.S., Mok, T.S. & Rebbeck, T.R. Cancer genomics: diversity and disparity across ethnicity and geography. J. Clin. Oncol. 34, 91–101 (2016).
Zhao, Y. et al. Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells. Oncogene 27, 1–8 (2008).
Brumbaugh, C.D., Kim, H.J., Giovacchini, M. & Pourmand, N. NanoStriDE: normalization and differential expression analysis of NanoString nCounter data. BMC Bioinformatics 12, 479 (2011).
Garrison, P., Yue, S., Hanson, J., Baron, J. & Lui, J.C. Spatial regulation of bone morphogenetic proteins (BMPs) in postnatal articular and growth plate cartilage. PLoS One 12, e0176752 (2017).
Cerami, E. et al. The cBio Cancer Genomics Portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2, 401–404 (2012).