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SPOP tips the balance of BETs in cancer

Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal inhibitors in prostate and endometrial cancer.

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Figure 1: SPOP mutants disrupt BET protein homeostasis in cancer.

Debbie Maizels/Springer Nature

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Correspondence to Mark A Dawson.

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Fennell, K., Dawson, M. SPOP tips the balance of BETs in cancer. Nat Med 23, 1014–1015 (2017). https://doi.org/10.1038/nm.4398

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