Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal inhibitors in prostate and endometrial cancer.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Mani, R.S. Drug Discov. Today 19, 1498–1502 (2014).
Le Gallo, M. et al. Nat. Genet. 44, 1310–1315 (2012).
Barbieri, C.E. et al. Nat. Genet. 44, 685–689 (2012).
Theurillat, J.P. et al. Science 346, 85–89 (2014).
Dai, X. et al. Nat. Med. 23, 1063–1071 (2017).
Zhang, P. et al. Nat. Med. 23, 1055–1062 (2017).
Janouskova, H. et al. Nat. Med. 23, 1046–1054 (2017).
Dawson, M.A. Science 355, 1147–1152 (2017).
Fong, C.Y. et al. Nature 525, 538–542 (2015).
Rathert, P. et al. Nature 525, 543–547 (2015).
Shu, S. et al. Nature 529, 413–417 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Fennell, K., Dawson, M. SPOP tips the balance of BETs in cancer. Nat Med 23, 1014–1015 (2017). https://doi.org/10.1038/nm.4398
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.4398