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Calculated risk: a new single-nucleotide polymorphism linked to severe influenza disease

Clear links between human genes and susceptibility to influenza disease are scarce. A recent study uncovers a gene variant coupled to severe influenza, and shows how it hampers the expression of an antiviral gene that is key to immune cell survival.

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Figure 1: The rs34481144 allele regulates IFITM3 expression and influenza severity.

Debbie Maizels/Springer Nature


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This study was funded by the Leading Advanced Projects for medical innovation (LEAP) from the Japan Agency for Medical Research and Development (AMED); and grant U19AI106772 (to Y.K.), provided by the National Institute of Allergy and Infectious Diseases, US National Institutes of Health. The authors thank S. Watson for editing the manuscript.

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Correspondence to Yoshihiro Kawaoka.

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Eisfeld, A., Kawaoka, Y. Calculated risk: a new single-nucleotide polymorphism linked to severe influenza disease. Nat Med 23, 911–912 (2017).

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