A new study that uses a triple-drug combination to overcome a major mechanism of drug resistance in cancer provides insights into the evolutionary paths taken by tumors in the face of selective pressure.
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References
Pratilas, C.A., Xing, F. & Solit, D.B. Curr. Top. Microbiol. Immunol. 355, 83–98 (2010).
Shi, H. et al. Nat. Commun. 3, 724 (2012).
Larkin, J. et al. N. Engl. J. Med. 371, 1867–1876 (2014).
Long, G.V. et al. N. Engl. J. Med. 371, 1877–1888 (2014).
Xue, Y. et al. Nat. Med. 23, 929–937 (2017).
Bock, C. & Lengauer, T. Nat. Rev. Cancer 12, 494–501 (2012).
Brioli, A., Melchor, L., Cavo, M. & Morgan, G.J. Br. J. Haematol. 165, 441–454 (2014).
Das Thakur, M. et al. Nature 494, 251–255 (2013).
Skoulidis, F. & Papadimitrakopoulou, V.A. Clin. Cancer Res. 23, 618–622 (2017).
Holderfield, M., Nagel, T.E. & Stuart, D.D. Br. J. Cancer 111, 640–645 (2014).
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A.J.F. and J.S. are both employees of Calico Life Sciences.
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Firestone, A., Settleman, J. A three-drug combination to treat BRAF-mutant cancers. Nat Med 23, 913–914 (2017). https://doi.org/10.1038/nm.4382
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DOI: https://doi.org/10.1038/nm.4382
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