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A mouse model of renal cell carcinoma

Nature Medicine volume 23, pages 802–803 (2017)Cite this article

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A mouse model with combined renal epithelium-specific deletion of Vhl, Trp53 and Rb1 that develops clear-cell renal cell carcinoma provides a research tool for investigating the mechanisms that drive this cancer, and for evaluating the efficacy of novel therapeutic agents.

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Figure 1: A genetically engineered mouse with kidney-targeted inactivation of Vhl, Trp53 and Rb1 that models human clear cell renal cell carcinoma.

Debbie Maizels/Springer Nature

References

  1. Ferlay, J. et al. Int. J. Cancer 127, 2893–2917 (2010).

    Article  CAS  Google Scholar 

  2. Linehan, W.M. Genome Res. 22, 2089–2100 (2012).

    Article  CAS  Google Scholar 

  3. Nickerson, M.L. et al. Clin. Cancer Res. 14, 4726–4734 (2008).

    Article  CAS  Google Scholar 

  4. Mandriota, S.J. et al. Cancer Cell 1, 459–468 (2002).

    Article  CAS  Google Scholar 

  5. Frew, I.J. & Moch, H. Annu. Rev. Pathol. 10, 263–289 (2015).

    Article  CAS  Google Scholar 

  6. Cancer Genome Atlas Research Network. Nature 499, 43–49 (2013).

  7. Sato, Y. et al. Nat. Genet. 45, 860–867 (2013).

    Article  CAS  Google Scholar 

  8. Harlander, S. et al. Nat. Med. 23, 869–877 (2017).

    Article  CAS  Google Scholar 

  9. Lehmann, H., Vicari, D., Wild, P.J. & Frew, I.J. J. Am. Soc. Nephrol. 26, 2778–2788 (2015).

    Article  CAS  Google Scholar 

  10. Guinot, A., Lehmann, H., Wild, P.J. & Frew, I.J. J. Pathol. 239, 365–373 (2016).

    Article  CAS  Google Scholar 

  11. Frew, I.J. et al. EMBO J. 27, 1747–1757 (2008).

    Article  CAS  Google Scholar 

  12. Wang, S.S. et al. Proc. Natl. Acad. Sci. USA 111, 16538–16543 (2014).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the Intramural Research Program of the US National Institutes of Health (NIH), National Cancer Institute (NCI), Center for Cancer Research. This work has been funded in part with Federal funds from the Frederick National Laboratory for Cancer Research, NIH, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsements by the US Government.

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Authors and Affiliations

  1. Basic Science Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

    Laura S Schmidt

  2. Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

    Laura S Schmidt, Laura S Schmidt & W Marston Linehan

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  1. Laura S Schmidt
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  2. W Marston Linehan
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Correspondence to W Marston Linehan.

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Schmidt, L., Linehan, W. A mouse model of renal cell carcinoma. Nat Med 23, 802–803 (2017). https://doi.org/10.1038/nm.4366

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