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An unexpected role for bile acid synthesis in adaptation to low temperature

Enhanced conversion of dietary cholesterol to bile acids through the alternative pathway leads to cold-associated, metabolically beneficial changes in the intestinal microbiome and to elevated bile acid levels that contribute to adaptive thermogenesis.

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Figure 1: The BAT–liver–intestine axis contributes to microbiome modulation and adaptive thermogenesis in cold-exposed mice fed a high-fat and high-cholesterol diet.

Debbie Maizels/Springer Nature


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Correspondence to Folkert Kuipers.

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Kuipers, F., Groen, A. An unexpected role for bile acid synthesis in adaptation to low temperature. Nat Med 23, 800–802 (2017).

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