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Understanding cancer from the stem cells up

A new study that uses an integrated single-cell transcriptomics approach to characterize cancer stem cell populations during treatment with molecularly targeted therapies offers insights into disease evolution and points to new therapeutic targets.

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Figure 1: The dynamics of cancer stem cell selection and evolution on targeted therapy.


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Correspondence to Brian J Druker.

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Competing interests

B.J.D. is currently principal investigator or co-investigator on Novartis and Bristol-Myers Squibb clinical trials. His institution, OHSU, has contracts with these companies to pay for patient costs, nurse and data-manager salaries, and institutional overhead. He does not derive a salary, and his lab does not receive funds from these contracts. OHSU and B.J.D. have a financial interest in MolecularMD, a company that may have a commercial interest in this research and technology. This potential individual and institutional conflict of interest has been reviewed and managed by OHSU.

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Eide, C., Druker, B. Understanding cancer from the stem cells up. Nat Med 23, 656–657 (2017).

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