A new study reveals that virus-associated activation of a subset of circulating monocytes results in the release of the proinflammatory cytokine tumor necrosis factor (TNF)-α, which induces increased turnover of synapses in the brain and learning deficits in mice.
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Priller, J., Böttcher, C. Patrolling monocytes sense peripheral infection and induce cytokine-mediated neuronal dysfunction. Nat Med 23, 659–661 (2017). https://doi.org/10.1038/nm.4349
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DOI: https://doi.org/10.1038/nm.4349
