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The cannabis paradox: when age matters

New evidence in mouse models reveals that exposure to Δ9-tetrahydrocannabinol (THC), the main psychoactive component in Cannabis sativa, might improve cognitive performance in aging animals.

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Figure 1: Bilkei-Gorzo et al.5 show in mature and old mice (12 and 18 months old, respectively) that THC increases the density of hippocampal synapses; the phosphorylation of signaling proteins involved in learning and memory; and levels of histone acetylation in the hippocampus.

Kim Caesar/Springer Nature


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Correspondence to Andrés Ozaita or Ester Aso.

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Ozaita, A., Aso, E. The cannabis paradox: when age matters. Nat Med 23, 661–662 (2017).

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