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Thymosin α1: a single drug with multiple targets in cystic fibrosis

A new study in mice suggests that a single drug, thymosin α1, may simultaneously rectify the impaired trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in cystic fibrosis (CF) and reduce inflammation, offering new hope for CF treatment.

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Figure 1: The multiple effects of Tα1 on pathophysiological mechanisms relevant to cystic fibrosis.

Kim Caesar/Springer Nature

References

  1. Spielberg, D.R. & Clancy, J.P. Annu. Rev. Genomics Hum. Genet. 17, 155–175 (2016).

    Article  CAS  Google Scholar 

  2. Romani, L. et al. Nat. Med. 23, 590–600 (2017).

    Article  CAS  Google Scholar 

  3. Sly, P.D. et al. N. Engl. J. Med. 368, 1963–1970 (2013).

    Article  CAS  Google Scholar 

  4. Shah, V.S. et al. Science 351, 503–507 (2016).

    Article  CAS  Google Scholar 

  5. Tang, X.X. et al. J. Clin. Invest. 126, 879–891 (2016).

    Article  Google Scholar 

  6. Hisert, K.B. et al. Am. J. Respir. Crit. Care Med. http://dx.doi.org/10.1164/rccm.201609-1954OC (2017).

  7. Atlante, A. et al. J. Bioenerg. Biomembr. 48, 197–210 (2016).

    Article  CAS  Google Scholar 

  8. Carlile, G.W. et al. J. Cyst. Fibros. 14, 16–25 (2015).

    Article  CAS  Google Scholar 

  9. Iannitti, R.G. et al. Nat. Commun. 7, 10791 (2016).

    Article  CAS  Google Scholar 

  10. Maghzal, G.J., Thomas, S.R., Hunt, N.H. & Stocker, R. J. Biol. Chem. 283, 12014–12025 (2008).

    Article  CAS  Google Scholar 

  11. Iannitti, R.G. et al. Am. J. Respir. Crit. Care Med. 187, 609–620 (2013).

    Article  CAS  Google Scholar 

  12. Low, T.L. et al. J. Biol. Chem. 254, 981–986 (1979).

    CAS  PubMed  Google Scholar 

Download references

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Correspondence to André M Cantin.

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Cantin, A., Hanrahan, J. Thymosin α1: a single drug with multiple targets in cystic fibrosis. Nat Med 23, 536–538 (2017). https://doi.org/10.1038/nm.4339

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