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A role for oncostatin M in inflammatory bowel disease

A new study identifies oncostatin M (OSM) as a potential biomarker and therapeutic target for anti-tumor necrosis factor (TNF)-refractory inflammatory bowel disease (IBD), and pinpoints mucosal stromal cells as key players in OSM-mediated inflammation.

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Figure 1: OSM and OSMR are upregulated in severe anti-TNF-therapy-refractive IBD.

Kim Caesar/Springer Nature


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The work was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (R01 DK044319, R01 DK051362, R01 DK053056 and R01 DK088199 to R.S.B.; and T32 DK007533 to W.M.K.).

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Correspondence to Richard S Blumberg.

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The authors declare no competing financial interests.

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Kim, W., Kaser, A. & Blumberg, R. A role for oncostatin M in inflammatory bowel disease. Nat Med 23, 535–536 (2017).

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