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A role for oncostatin M in inflammatory bowel disease

Nature Medicine volume 23, pages 535536 (2017) | Download Citation

A new study identifies oncostatin M (OSM) as a potential biomarker and therapeutic target for anti-tumor necrosis factor (TNF)-refractory inflammatory bowel disease (IBD), and pinpoints mucosal stromal cells as key players in OSM-mediated inflammation.

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Acknowledgements

The work was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (R01 DK044319, R01 DK051362, R01 DK053056 and R01 DK088199 to R.S.B.; and T32 DK007533 to W.M.K.).

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Affiliations

  1. Walter M. Kim and Richard S. Blumberg are in the Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

    • Walter M Kim
    •  & Richard S Blumberg
  2. Arthur Kaser is in the Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, UK.

    • Arthur Kaser

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Richard S Blumberg.

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DOI

https://doi.org/10.1038/nm.4338

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