Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A role for oncostatin M in inflammatory bowel disease

A new study identifies oncostatin M (OSM) as a potential biomarker and therapeutic target for anti-tumor necrosis factor (TNF)-refractory inflammatory bowel disease (IBD), and pinpoints mucosal stromal cells as key players in OSM-mediated inflammation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: OSM and OSMR are upregulated in severe anti-TNF-therapy-refractive IBD.

Kim Caesar/Springer Nature


  1. Molodecky, N.A. et al. Gastroenterology 142, 46–54 (2012).

    Article  Google Scholar 

  2. Guerra, I. & Bermejo, F. Clin. Exp. Gastroenterol. 7, 359–367 (2014).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Feagan, B.G. et al. N. Engl. J. Med. 369, 699–710 (2013).

    Article  CAS  Google Scholar 

  4. Feagan, B.G. et al. N. Engl. J. Med. 375, 1946–1960 (2016).

    Article  CAS  Google Scholar 

  5. Sands, B.E. et al. Inflamm. Bowel Dis. 23, 97–106 (2017).

    Article  Google Scholar 

  6. West, N.R. et al. Nat. Med. 23, 579–589 (2017).

    Article  CAS  Google Scholar 

  7. Hermanns, H. Cytokine Growth Factor Rev. 26, 545–558 (2015).

    Article  CAS  Google Scholar 

  8. Sanchez, A. et al. J. Interferon Cytokine Res. 23, 193–201 (2003).

    Article  CAS  Google Scholar 

  9. Beigel, F. et al. PLoS One 9, e93498 (2014).

    Article  Google Scholar 

  10. Sandborn, W.J. et al. Gastroenterology 146, 85–95 (2014).

    Article  CAS  Google Scholar 

  11. Kullberg, M.C. et al. J. Exp. Med. 203, 2485–2494 (2006).

    Article  CAS  Google Scholar 

  12. Kullberg, M.C. et al. Infect. Immun. 69, 4232–4241 (2001).

    Article  CAS  Google Scholar 

Download references


The work was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (R01 DK044319, R01 DK051362, R01 DK053056 and R01 DK088199 to R.S.B.; and T32 DK007533 to W.M.K.).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Richard S Blumberg.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kim, W., Kaser, A. & Blumberg, R. A role for oncostatin M in inflammatory bowel disease. Nat Med 23, 535–536 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing