Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A mouse recapitulating APOL1-associated kidney disease

In a recent study, researchers generated a mouse model expressing variant APOL1 that recapitulates human kidney disease. Variant APOL1 leads to caspase-1-dependent pyroptosis, which opens the door for the development of new druggable targets to treat APOL1-mediated kidney disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Disruption of the autophagocytic pathway in podocytes by the APOL1 G1 and G2 risk alleles.

Kim Caesar/Springer Nature


  1. Genovese, G. et al. Science 329, 841–845 (2010).

    Article  CAS  Google Scholar 

  2. Kruzel-Davila, E. et al. J. Am. Soc. Nephrol. (2016).

  3. Ma, L. et al. J. Am. Soc. Nephrol. (2016).

  4. Thomson, R. et al. Proc. Natl. Acad. Sci. USA 111, E2130–E2139 (2014).

    Article  CAS  Google Scholar 

  5. Vanwalleghem, G. et al. Nat. Commun. 6, 8078 (2015).

    Article  CAS  Google Scholar 

  6. Beckerman, P. et al. Nat. Med. 23, 429–438 (2017).

    Article  CAS  Google Scholar 

  7. Bruggeman, L.A. et al. J. Am. Soc. Nephrol. 27, 3600–3610 (2016).

    Article  CAS  Google Scholar 

  8. Larsen, C.P. et al. Mod. Pathol. 28, 95–102 (2015).

    Article  Google Scholar 

  9. Vezzani, A. et al. Curr. Opin. Investig. Drugs 11, 43–50 (2010).

    CAS  PubMed  Google Scholar 

  10. Dummer, P.D. et al. Semin. Nephrol. 35, 222–236 (2015).

    Article  CAS  Google Scholar 

  11. Nichols, B. et al. Kidney Int. 87, 332–342 (2015).

    Article  CAS  Google Scholar 

  12. Limou, S., Dummer, P.D., Nelson, G.W., Kopp, J.B. & Winkler, C.A. Kidney Int. 88, 28–34 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Cheryl A Winkler.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Winkler, C., Nelson, G. A mouse recapitulating APOL1-associated kidney disease. Nat Med 23, 411–412 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing