A recent study shows that a self-peptide generated in pancreatic islet beta cells through the translation of a noncanonical alternative reading frame in human insulin mRNA is recognized by both CD4+ and CD8+ T cells in type 1 diabetes.
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The authors are supported by the Division of Intramural Research, NIAID, Bethesda, Maryland.
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Wei, J., Yewdell, J. Autoimmune T cell recognition of alternative-reading-frame-encoded peptides. Nat Med 23, 409–410 (2017). https://doi.org/10.1038/nm.4317
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DOI: https://doi.org/10.1038/nm.4317
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