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The Drug Repurposing Hub: a next-generation drug library and information resource

Nature Medicine volume 23, pages 405408 (2017) | Download Citation

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Acknowledgements

We thank the members of the Broad Institute Compound Management team for their invaluable assistance. We also thank C. Yu, J. Boehm, N. Tolliday, J. Athanasopoulos, J. Rosains, S. Loranger, and A. Burgin for helpful scientific discussions. This work was supported in part by NIH LINCS Program grants 3U54 HG006093 (T.R.G. and A.S.), U54 HL127366 (T.R.G. and A.S.), and U54 HG008699 (T.R.G. and A.S.). Additional support was provided by the Howard Hughes Medical Institute (T.R.G.), NIH training grant T32 CA009172 (S.M.C.), KL2/Catalyst Medical Research Investigator Training award from Harvard Catalyst/The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health) Award KL2 TR001100 (S.M.C.), and the Conquer Cancer Foundation of ASCO Young Investigator Award (S.M.C.).

Author information

Affiliations

  1. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

    • Steven M Corsello
    • , Joshua A Bittker
    • , Zihan Liu
    • , Joshua Gould
    • , Patrick McCarren
    • , Jodi E Hirschman
    • , Stephen E Johnston
    • , Anita Vrcic
    • , Bang Wong
    • , Mariya Khan
    • , Jacob Asiedu
    • , Rajiv Narayan
    • , Christopher C Mader
    • , Aravind Subramanian
    •  & Todd R Golub
  2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

    • Steven M Corsello
  3. Harvard Medical School, Boston, Massachusetts, USA.

    • Steven M Corsello
    •  & Todd R Golub
  4. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

    • Todd R Golub
  5. Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.

    • Todd R Golub

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Contributions

S.M.C. and T.R.G. conceived the project, designed experiments, and wrote the paper with input from coauthors; A.V., S.E.J., P.M., and J.A.B. performed analytical chemistry and compound management activities; P.M., J.A.B., and S.M.C. performed chemical-structure analysis; S.M.C., Z.L., J.E.H., R.N., and C.C.M. annotated drug properties; B.W. and M.K. designed the Drug Repurposing Hub web-portal interface and assisted with manuscript figures; J.G., J.A., and A.S. designed and implemented the hub database, interactive web platform, and data API.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Todd R Golub.

Supplementary information

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    Supplementary Figures & Tables

    Supplementary Figures 1–6 & Supplementary Tables 1–4

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DOI

https://doi.org/10.1038/nm.4306

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