Taking inventory of metastasis effectors

In a recent study in mice, researchers combined tumor barcoding with unbiased genomic analysis and identified Cd109 as a hub gene involved in metastatic progression. They show that pharmacological inhibition of its downstream effectors JAK1 and STAT3 curtails metastatic growth.

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Figure 1: A molecular barcoding system unravels mechanisms of metastatic progression in lung adenocarcinoma.

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Correspondence to Cyrus M Ghajar.

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Pisarsky, L., Dai, J. & Ghajar, C. Taking inventory of metastasis effectors. Nat Med 23, 275–276 (2017). https://doi.org/10.1038/nm.4301

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