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Taking inventory of metastasis effectors

Nature Medicine volume 23, pages 275276 (2017) | Download Citation

In a recent study in mice, researchers combined tumor barcoding with unbiased genomic analysis and identified Cd109 as a hub gene involved in metastatic progression. They show that pharmacological inhibition of its downstream effectors JAK1 and STAT3 curtails metastatic growth.

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Author information

Author notes

    • Laura Pisarsky
    •  & Jinxiang Dai

    Laura Pisarsky and Jinxiang Dai contributed equally to this work.

Affiliations

  1. Laura Pisarsky, Jinxiang Dai and Cyrus M. Ghajar are in the Public Health Sciences Division's Translational Research Program and the Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

    • Laura Pisarsky
    • , Jinxiang Dai
    •  & Cyrus M Ghajar

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Cyrus M Ghajar.

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DOI

https://doi.org/10.1038/nm.4301

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