The production of neutrophil extracellular traps (NETs) is a process that enables neutrophils to help catch and kill bacteria. However, increasing evidence suggests that this process might also occur in noninfectious, sterile inflammation. In this Review, we describe the role of NETosis in autoimmunity, coagulation, acute injuries and cancer, and discuss NETs as potential therapeutic targets. Furthermore, we consider whether extracellular DNA is always detrimental in sterile inflammation and whether the source is always NETs.
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We thank C. Deppermann for proofreading the manuscript. Work in the authors' laboratory is supported by grants from the Canadian Institutes of Health Research, Alberta Innovates Health Solutions, the Heart and Stroke Foundation of Canada and the Canada Research Chairs program.
The authors declare no competing financial interests.
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Jorch, S., Kubes, P. An emerging role for neutrophil extracellular traps in noninfectious disease. Nat Med 23, 279–287 (2017). https://doi.org/10.1038/nm.4294
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