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HDAC3 sets the timer on muscle fuel switching

Nature Medicine volume 23, pages 148–150 (2017)Cite this article

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In a recent study in mice, it is shown that circadian oscillations in genomic histone deactylase 3 (HDAC3) occupancy influence fuel switching and carbon flux in muscle to regulate glucose homeostasis and exercise performance.

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Figure 1: HDAC3, an epigenetic modifier controlled by the circadian clock, mediates reciprocal regulation of amino acid and glucose catabolism.

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  1. Deborah M. Muoio is at the Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA.,

    Deborah M Muoio

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  1. Deborah M Muoio
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Correspondence to Deborah M Muoio.

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The author declares no competing financial interests.

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Muoio, D. HDAC3 sets the timer on muscle fuel switching. Nat Med 23, 148–150 (2017). https://doi.org/10.1038/nm.4282

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