Opioids: keeping the good, eliminating the bad

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Two new studies show that mechanisms mediating the opioid side effects of tolerance, hyperalgesia and physical dependence are mediated spinally and can be dissociated from analgesia. These side effects can be selectively targeted by clinically available drugs without affecting their pain-relieving effects.

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Figure 1: Spinal and peripheral mediation of opioid side effects.

Marina Corral Spence/Springer Nature

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Correspondence to Howard B Gutstein.

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Puig, S., Gutstein, H. Opioids: keeping the good, eliminating the bad. Nat Med 23, 272–273 (2017). https://doi.org/10.1038/nm.4277

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