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Opioids: keeping the good, eliminating the bad

Nature Medicine volume 23, pages 272273 (2017) | Download Citation

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Two new studies show that mechanisms mediating the opioid side effects of tolerance, hyperalgesia and physical dependence are mediated spinally and can be dissociated from analgesia. These side effects can be selectively targeted by clinically available drugs without affecting their pain-relieving effects.

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Author information

Affiliations

  1. Stephanie Puig and Howard B. Gutstein are in the Department of Anesthesiology and Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

    • Stephanie Puig
    •  & Howard B Gutstein

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Howard B Gutstein.

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DOI

https://doi.org/10.1038/nm.4277

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