Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A microbial protein that alleviates metabolic syndrome

A recent study shows that pasteurization of Akkermansia muciniphila enhances the bacterium's ability to reduce fat mass and metabolic syndrome in mice with diet-induced obesity, and that Amuc_1100*, a thermostable outer-membrane protein of A. muciniphila, can reproduce these beneficial effects.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Pasteurized Akkermansia muciniphila and its outer-membrane protein Amuc_1100* improve gut-barrier integrity and metabolic syndrome in mice with diet-induced obesity.

Marina Corral Spence/Springer Nature


  1. Belzer, C. & de Vos, W.M. ISME J. 6, 1449–1458 (2012).

    Article  CAS  Google Scholar 

  2. Derrien, M., Vaughan, E.E., Plugge, C.M. & de Vos, W.M. Int. J. Syst. Evol. Microbiol. 54, 1469–1476 (2004).

    Article  CAS  Google Scholar 

  3. Derrien, M., Collado, M.C., Ben-Amor, K., Salminen, S. & de Vos, W.M. Appl. Environ. Microbiol. 74, 1646–1648 (2008).

    Article  CAS  Google Scholar 

  4. Wang, L. et al. Appl. Environ. Microbiol. 77, 6718–6721 (2011).

    Article  CAS  Google Scholar 

  5. Derrien, M., Belzer, C. & de Vos, W.M. Microb. Pathog. (2016).

  6. Everard, A. et al. Proc. Natl. Acad. Sci. USA 110, 9066–9071 (2013).

    Article  CAS  Google Scholar 

  7. Shin, N.R. et al. Gut 63, 727–735 (2014).

    Article  CAS  Google Scholar 

  8. Li, J., Lin, S., Vanhoutte, P.M., Woo, C.W. & Xu, A. Circulation 133, 2434–2446 (2016).

    Article  CAS  Google Scholar 

  9. Plovier, H. et al. Nat. Med. 23, 107–113 (2017).

    Article  CAS  Google Scholar 

  10. Ottman, N. et al. Front. Microbiol. 7, 1157 (2016).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to André Marette.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Anhê, F., Marette, A. A microbial protein that alleviates metabolic syndrome. Nat Med 23, 11–12 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing