Figure 1 : Pasteurized Akkermansia muciniphila and its outer-membrane protein Amuc_1100* improve gut-barrier integrity and metabolic syndrome in mice with diet-induced obesity.

From: A microbial protein that alleviates metabolic syndrome

Figure 1

Left, obesity is associated with lower abundance of A. muciniphila in the gut microbiota than in healthy mice. This promotes a dysbiotic state in the intestinal microbiota, accompanied by disruption of the intestinal barrier, which favors the leakage of bacterial lipopolysaccharides (LPSs) into the circulation (i.e., metabolic endotoxemia). These mice also have increased visceral adiposity and impaired insulin sensitivity in muscle and liver when compared to healthy mice. Right, Plovier et al.9 show that the administration of either pasteurized A. muciniphila or its outer-membrane protein Amuc_1100* activates toll-like receptor 2 (TLR2), which, in the murine intestine, is localized to the apical border of villi and crypts. Treatment with pasteurized A. muciniphila or Amuc_1100* increased the expression of genes encoding the tight-junction proteins claudin 3 and occludin potentially as a result of signaling through TLR2 (as indicated by question mark). Both pasteurized A. muciniphila and Amuc_1100* alleviated metabolic endotoxemia in HFD-fed mice, which markedly improved glucose and lipid metabolism and reduced fat mass. Image: Marina Corral Spence/Springer Nature