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Diversity and collaboration for effective immunotherapy

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Tumors continue to escape therapies that target single signaling pathways. A recent study in mice shows that combination immunotherapy involving different arms of immune response can overcome this and cure intractable tumors.

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Figure 1: Combination therapy to launch curative immunity.

Katie Vicari/Springer Nature

References

  1. Postow, M.A., Callahan, M.K. & Wolchok, J.D. J. Clin. Oncol. 33, 1974–1982 (2015).

    CAS  Article  Google Scholar 

  2. Topalian, S.L., Taube, J.M., Anders, R.A. & Pardoll, D.M. Nat. Rev. Cancer 16, 275–287 (2016).

    CAS  Article  Google Scholar 

  3. Sharma, P. & Allison, J.P. Science 348, 56–61 (2015).

    CAS  Article  Google Scholar 

  4. Moynihan, K.D. et al. Nat. Med. 22, 1402–1410 (2016).

    CAS  Article  Google Scholar 

  5. Pulendran, B. Annu. Rev. Immunol. 33, 563–606 (2015).

    CAS  Article  Google Scholar 

  6. Stromnes, I.M. et al. Cancer Cell 28, 638–652 (2015).

    CAS  Article  Google Scholar 

  7. Palucka, K. & Banchereau, J. Cell 157, 516–516.e1 (2014).

    CAS  Article  Google Scholar 

  8. Palucka, A.K. & Coussens, L.M. Cell 164, 1233–1247 (2016).

    CAS  Article  Google Scholar 

  9. Larkin, J. et al. N. Engl. J. Med. 373, 23–34 (2015).

    Article  Google Scholar 

  10. Hildner, K. et al. Science 322, 1097–1100 (2008).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Karolina Palucka.

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Competing interests

Karolina Palucka does consulting for MedImmune and Merck, and declares grant support from Merck.

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Palucka, K., Banchereau, J. Diversity and collaboration for effective immunotherapy. Nat Med 22, 1390–1391 (2016). https://doi.org/10.1038/nm.4249

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