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Spermidine to the rescue for an aging heart

A recent study shows that spermidine has beneficial effects on health and lifespan in mice, and that these effects are the result of improved cardiovascular function. Similar effects of spermidine on humans are supported by epidemiological studies.

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Figure 1: The effects of spermidine on aging and cardiovascular health.

Katie Vicari/Springer Nature


  1. Eisenberg, T. et al. Nat. Med. 22, 1428–1438 (2016)

    Article  CAS  Google Scholar 

  2. Pegg, A.E. J. Biol. Chem. 291, 14904–14912 (2016).

    Article  CAS  Google Scholar 

  3. Eisenberg, T. et al. Nat. Cell Biol. 11, 1305–1314 (2009).

    Article  CAS  Google Scholar 

  4. Taneike, M. et al. Autophagy 6, 600–606 (2010).

    Article  CAS  Google Scholar 

  5. de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M.N. & Madeo, F. Cell 157, 1515–1526 (2014).

    Article  CAS  Google Scholar 

  6. López-Otín, C., Galluzzi, L., Freije, J.M., Madeo, F. & Kroemer, G. Cell 166, 802–821 (2016).

    Article  Google Scholar 

  7. Morselli, E. et al. J. Cell Biol. 192, 615–629 (2011).

    Article  CAS  Google Scholar 

  8. Diaz, M., Degens, H., Vanhees, L., Austin, C. & Azzawi, M. Exp. Gerontol. 85, 41–47 (2016).

    Article  CAS  Google Scholar 

  9. Minois, N. Gerontology 60, 319–326 (2014).

    Article  CAS  Google Scholar 

  10. Soda, K. et al. J. Nutr. Sci. Vitaminol. (Tokyo) 55, 361–366 (2009).

    Article  CAS  Google Scholar 

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Correspondence to Rafael de Cabo.

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de Cabo, R., Navas, P. Spermidine to the rescue for an aging heart. Nat Med 22, 1389–1390 (2016).

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