Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Spermidine to the rescue for an aging heart

A recent study shows that spermidine has beneficial effects on health and lifespan in mice, and that these effects are the result of improved cardiovascular function. Similar effects of spermidine on humans are supported by epidemiological studies.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The effects of spermidine on aging and cardiovascular health.

Katie Vicari/Springer Nature

References

  1. Eisenberg, T. et al. Nat. Med. 22, 1428–1438 (2016)

    Article  CAS  Google Scholar 

  2. Pegg, A.E. J. Biol. Chem. 291, 14904–14912 (2016).

    Article  CAS  Google Scholar 

  3. Eisenberg, T. et al. Nat. Cell Biol. 11, 1305–1314 (2009).

    Article  CAS  Google Scholar 

  4. Taneike, M. et al. Autophagy 6, 600–606 (2010).

    Article  CAS  Google Scholar 

  5. de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M.N. & Madeo, F. Cell 157, 1515–1526 (2014).

    Article  CAS  Google Scholar 

  6. López-Otín, C., Galluzzi, L., Freije, J.M., Madeo, F. & Kroemer, G. Cell 166, 802–821 (2016).

    Article  Google Scholar 

  7. Morselli, E. et al. J. Cell Biol. 192, 615–629 (2011).

    Article  CAS  Google Scholar 

  8. Diaz, M., Degens, H., Vanhees, L., Austin, C. & Azzawi, M. Exp. Gerontol. 85, 41–47 (2016).

    Article  CAS  Google Scholar 

  9. Minois, N. Gerontology 60, 319–326 (2014).

    Article  CAS  Google Scholar 

  10. Soda, K. et al. J. Nutr. Sci. Vitaminol. (Tokyo) 55, 361–366 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rafael de Cabo.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

de Cabo, R., Navas, P. Spermidine to the rescue for an aging heart. Nat Med 22, 1389–1390 (2016). https://doi.org/10.1038/nm.4243

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.4243

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing