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Innate immune signaling and stem cell renewal in idiopathic pulmonary fibrosis

Aberrant injury responses in the distal lung likely underpin the development of idiopathic pulmonary fibrosis (IPF). A recent study shows that defective Toll-like receptor 4 (TLR4)-mediated hyaluronan binding impairs alveolar type 2 cell renewal, which may contribute to a dysregulated lung-injury response in IPF.

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Figure 1: AEC2 cell renewal and response to injury is impaired in IPF.


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Correspondence to Rachel C Chambers.

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Mercer, P., Chambers, R. Innate immune signaling and stem cell renewal in idiopathic pulmonary fibrosis. Nat Med 22, 1210–1212 (2016).

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