Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Caspase-2 and tau—a toxic partnership?

Misfolded and hyperphosphorylated forms of the microtubule-associated protein tau are thought to be responsible for some degree of neurodegeneration. The demonstration of a novel toxic cleavage of tau by caspase-2 opens up new therapeutic avenues.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Caspase-2 cleavage of tau.

Katie Vicari/Nature Publishing Group

References

  1. Weingarten, M.D., Lockwood, A.H., Hwo, S.Y. & Kirschner, M.W. Proc. Natl. Acad. Sci. USA 72, 1858–1862 (1975).

    Article  CAS  Google Scholar 

  2. Migheli, A., Butler, M., Brown, K. & Shelanski, M.L. J. Neurosci. 8, 1846–1851 (1988).

    Article  CAS  Google Scholar 

  3. Cleveland, D.W., Hwo, S.Y. & Kirschner, M.W. J. Mol. Biol. 116, 207–225 (1977).

    Article  CAS  Google Scholar 

  4. Goedert, M., Spillantini, M.G., Cairns, N.J. & Crowther, R.A. Neuron 8, 159–168 (1992).

    Article  CAS  Google Scholar 

  5. Terry, R.D. J. Neuropathol. Exp. Neurol. 22, 629–642 (1963).

    Article  CAS  Google Scholar 

  6. Kidd, M. Nature 197, 192–193 (1963).

    Article  CAS  Google Scholar 

  7. Spillantini, M.G. & Goedert, M. Trends Neurosci. 21, 428–433 (1998).

    Article  CAS  Google Scholar 

  8. Wang, Y., Garg, S., Mandelkow, E.-M. & Mandelkow, E. Biochem. Soc. Trans. 38, 955–961 (2010).

    Article  CAS  Google Scholar 

  9. Rissman, R.A. et al. J. Clin. Invest. 114, 121–130 (2004).

    Article  CAS  Google Scholar 

  10. Zhao, X. et al. Nat. Med. 22, 1268–1276, (2016).

    Article  CAS  Google Scholar 

  11. Troy, C.M. et al. J. Neurosci. 20, 1386–1392 (2000).

    Article  CAS  Google Scholar 

  12. Pozueta, J. et al. Nat. Commun. 1939, 4 (2013).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael L Shelanski.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Troy, C., Shelanski, M. Caspase-2 and tau—a toxic partnership?. Nat Med 22, 1207–1208 (2016). https://doi.org/10.1038/nm.4227

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.4227

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing