A new study presents a protocol to differentiate human induced pluripotent stem cells (iPSCs) into microglia that closely resemble their in vivo counterparts. These cells offer an exciting new tool for learning more about the role of microglia in disease.
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References
Hong, S. & Stevens, B. Dev. Cell 38, 126–128 (2016).
Sterneckert, J.L., Reinhardt, P. & Schöler, H.R. Nat. Rev. Genet. 15, 625–639 (2014).
Muffat, J. et al. Nat. Med. 22, 1358–1367 (2016).
Ginhoux, F. et al. Science 330, 841–845 (2010).
Hickman, S.E. et al. Nat. Neurosci. 16, 1896–1905 (2013).
Gomez Perdiguero, E. et al. Nature 518, 547–551 (2015).
Mass, E. et al. Science, http://dx.doi.org/10.1126/science.aaf4238 (2016).
Lavin, Y. et al. Cell 159, 1312–1326 (2014).
Gosselin, D. et al. Cell 159, 1327–1340 (2014).
Li, Y. et al. Cell Stem Cell 13, 446–458 (2013).
Schafer, D.P. et al. eLife 5, e15224 (2016).
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Hammond, T., Stevens, B. Increasing the neurological-disease toolbox using iPSC-derived microglia. Nat Med 22, 1206–1207 (2016). https://doi.org/10.1038/nm.4226
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DOI: https://doi.org/10.1038/nm.4226
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