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Reply to "Neutrophils are not required for resolution of acute gouty arthritis in mice"


An Erratum to this article was published on 07 April 2017

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Figure 1: Degradation of cytokines and chemokines by mouse MSU crystal aggregates.
Figure 2: Role of neutrophils in the formation of MSU crystal aggregates and MSU crystal induced arthritis.

Change history

  • 19 January 2017

    In the version of this article initially published, the units (ml) for values reported in the methods are incorrect. The correct unit should be µl. The error has been corrected in the HTML and PDF versions of the article.


  1. Schauer, C. et al. Nat. Med. 20, 511–517 (2014).

    Article  CAS  Google Scholar 

  2. Reber, L.L., Gaudenzio, N., Starkl, P. & Galli, S.J. Nat. Med. 22, 1382–1384 (2016).

    Article  CAS  Google Scholar 

  3. Mestas, J. & Hughes, C.C.W. J. Immunol. 172, 2731–2738 (2004).

    Article  CAS  Google Scholar 

  4. Hajjar, E., Broemstrup, T., Kantari, C., Witko-Sarsat, V. & Reuter, N. FEBS J. 277, 2238–2254 (2010).

    Article  CAS  Google Scholar 

  5. Dalbeth, N. et al. Arthritis Rheum. 62, 1549–1556 (2010).

    Article  CAS  Google Scholar 

  6. Daley, J.M., Thomay, A.A., Connolly, M.D., Reichner, J.S. & Albina, J.E. J. Leukoc. Biol. 83, 64–70 (2008).

    Article  CAS  Google Scholar 

  7. Ordoñez-Rueda, D. et al. Eur. J. Immunol. 42, 2395–2408 (2012).

    Article  Google Scholar 

  8. Dzhagalov, I., St John, A. & He, Y.-W. Blood 109, 1620–1626 (2007).

    Article  CAS  Google Scholar 

  9. Schorn, C. et al. Front. Immunol. 3, 277 (2012).

    PubMed  PubMed Central  Google Scholar 

  10. Morshed, M. et al. J. Immunol. 192, 5314–5323 (2014).

    Article  CAS  Google Scholar 

  11. Yousefi, S. et al. Nat. Med. 14, 949–953 (2008).

    Article  CAS  Google Scholar 

  12. von Köckritz-Blickwede, M. et al. Blood 111, 3070–3080 (2008).

    Article  Google Scholar 

  13. Reber, L.L. et al. Arthritis Rheumatol. 66, 2881–2891 (2014).

    Article  CAS  Google Scholar 

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This project was supported by the German Research Foundation (DFG CRC1181, project C03 to M. Herrmann and M. Hoffmann; project Ho5193/1-1 to M. Hoffmann; and project H34490/6-1 to M. Herrmann) and by the Interdisciplinary Center for Clinical Research (IZKF) at the university hospital of the University of Erlangen-Nuremberg (project J41 to C.S.).

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Authors and Affiliations



C.R. and C.S. planned and performed most of the experiments, conducted data analysis and prepared the figures. J.Z.C. planned and performed experiments with LysM-Cre+Mcl1f/f and LysM-Cre+Mcl1+/+ mice. D.K. and D.W. planned and performed histological analysis and mast cell stainings. M.M. provided the Genista mouse strain and discussed the strategy of the experiments. A.M. provided LysM-Cre+Mcl1f/f and LysM-Cre+Mcl1+/+ mice and discussed the strategy of the experiments. G.S. and M. Herrmann provided scientific input and planned the strategy of the experiments. M. Hoffmann supervised the project, planned experiments, conducted data analysis and wrote the manuscript. All authors read and approved the manuscript.

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Correspondence to Markus Hoffmann.

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The authors declare no competing financial interests.

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Reinwald, C., Schauer, C., Csepregi, J. et al. Reply to "Neutrophils are not required for resolution of acute gouty arthritis in mice". Nat Med 22, 1384–1386 (2016).

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