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Reply to "Neutrophils are not required for resolution of acute gouty arthritis in mice"

Nature Medicine volume 22, pages 1384–1386 (2016)Cite this article

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An Erratum to this article was published on 07 April 2017

This article has been updated

Reinwald et al. reply:

In their correspondence regarding our publication in Nature Medicine1, Reber et al.2 confirm our conclusions about the degradation of inflammatory mediators by aggregates forming in the presence of monosodium urate (MSU) crystals and high concentrations of human blood neutrophils (aggNETs). By contrast, they conclude that mouse MSU crystal aggregates formed in vitro by mouse bone marrow neutrophils or in vivo in the peritoneum do not degrade cytokines or chemokines.

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Figure 1: Degradation of cytokines and chemokines by mouse MSU crystal aggregates.
Figure 2: Role of neutrophils in the formation of MSU crystal aggregates and MSU crystal induced arthritis.

Change history

  • 19 January 2017

    In the version of this article initially published, the units (ml) for values reported in the methods are incorrect. The correct unit should be µl. The error has been corrected in the HTML and PDF versions of the article.

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Acknowledgements

This project was supported by the German Research Foundation (DFG CRC1181, project C03 to M. Herrmann and M. Hoffmann; project Ho5193/1-1 to M. Hoffmann; and project H34490/6-1 to M. Herrmann) and by the Interdisciplinary Center for Clinical Research (IZKF) at the university hospital of the University of Erlangen-Nuremberg (project J41 to C.S.).

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Author notes

  1. Christiane Reinwald and Christine Schauer: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany

    Christiane Reinwald, Christine Schauer, Deborah Kienhöfer, Daniela Weidner, Georg Schett, Martin Herrmann & Markus Hoffmann

  2. Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary

    Janka Zsófia Csepregi & Attila Mocsai

  3. Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm U1104, CNRS UMR7280, Marseille, France

    Marie Malissen

  4. MTA-SE “Lendület” Inflammation Physiology Research Group of the Hungarian Academy of Sciences and the Semmelweis University, Budapest, Hungary

    Attila Mocsai

Authors
  1. Christiane Reinwald
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Contributions

C.R. and C.S. planned and performed most of the experiments, conducted data analysis and prepared the figures. J.Z.C. planned and performed experiments with LysM-Cre+Mcl1f/f and LysM-Cre+Mcl1+/+ mice. D.K. and D.W. planned and performed histological analysis and mast cell stainings. M.M. provided the Genista mouse strain and discussed the strategy of the experiments. A.M. provided LysM-Cre+Mcl1f/f and LysM-Cre+Mcl1+/+ mice and discussed the strategy of the experiments. G.S. and M. Herrmann provided scientific input and planned the strategy of the experiments. M. Hoffmann supervised the project, planned experiments, conducted data analysis and wrote the manuscript. All authors read and approved the manuscript.

Corresponding author

Correspondence to Markus Hoffmann.

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The authors declare no competing financial interests.

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Reinwald, C., Schauer, C., Csepregi, J. et al. Reply to "Neutrophils are not required for resolution of acute gouty arthritis in mice". Nat Med 22, 1384–1386 (2016). https://doi.org/10.1038/nm.4217

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