Tumors often overexpress enzymes that synthesize fatty acids, but the requirement for fatty acid synthesis in tumor growth is unclear. A new fatty acid–synthesis inhibitor blunts lung tumor growth in mice, which implicates this process as a targetable liability.
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R.J.D. is an advisor for Agios Pharmaceuticals.
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Kim, J., DeBerardinis, R. Blocking fatty acid synthesis reduces lung tumor growth in mice. Nat Med 22, 1077–1078 (2016). https://doi.org/10.1038/nm.4195
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DOI: https://doi.org/10.1038/nm.4195
