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Dysregulated exocytosis of angiopoietin-2 drives cerebral cavernous malformation

Nature Medicine volume 22, pages 971973 (2016) | Download Citation

A new study has proposed a mechanism for the pathogenesis of cerebral cavernous malformation (CCM) that links endothelial CCM3 deficiency to increased secretion of the vascular destabilizing protein angiopoietin-2 (ANGPT2).

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Author information

Affiliations

  1. Helong Zhao and Tara M. Mleynek are in the Molecular Medicine Program, School of Medicine, University of Utah, Salt Lake City, Utah, USA.

    • Helong Zhao
    •  & Tara M Mleynek
  2. Dean Y. Li is at the School of Medicine and Health Sciences, University of Utah, Salt Lake City, Utah, USA.

    • Dean Y Li

Authors

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Competing interests

D.Y.L. is cofounder of the biotechnology companies Navigen and Recursion Pharmaceuticals.

Corresponding author

Correspondence to Dean Y Li.

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DOI

https://doi.org/10.1038/nm.4178

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