A new study has proposed a mechanism for the pathogenesis of cerebral cavernous malformation (CCM) that links endothelial CCM3 deficiency to increased secretion of the vascular destabilizing protein angiopoietin-2 (ANGPT2).
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D.Y.L. is cofounder of the biotechnology companies Navigen and Recursion Pharmaceuticals.
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Zhao, H., Mleynek, T. & Li, D. Dysregulated exocytosis of angiopoietin-2 drives cerebral cavernous malformation. Nat Med 22, 971–973 (2016). https://doi.org/10.1038/nm.4178
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DOI: https://doi.org/10.1038/nm.4178
